5/7/2023 0 Comments Royal tsx edit document text![]() ![]() Mycobacterium ulcerans, causing infections since ancient times, requires specific environmental conditions as reflected nowadays in its distribution worldwide. ![]() It has been hypothesized that the genus Mycobacterium originated more than 150 million years ago. Īncient times: the first historical records ĭue to its infectious nature, complex immunological response, chronic progression and the need for long-term treatment, TB has always been a major health burden in more recent years, the appearance of multi-drug resistant forms and the current TB-HIV epidemic, associated with its severe social implications, treating and preventing TB have represented a permanent challenge over the course of human history. TB has always been associated with a high mortality rate over the centuries, and also nowadays, it is estimated to be responsible for 1.4 million TB deaths, among infectious diseases after human immunodeficiency virus (HIV). MT has very ancient origins: it has survived over 70,000 years and it currently infects nearly 2 billion people worldwide with around 10.4 million new cases of TB each year, almost one third of the world's population are carriers of the TB bacillus and are at risk for developing active disease. Tuberculosis (TB) is a contagious, infectious disease, due to Mycobacterium tuberculosis (MT), which usually lasts throughout the life course and determines the formation of tubercles in different parts of the body. In the decades following this discovery, the Pirquet and Mantoux tuberculin skin tests, Albert Calmette and Camille Guérin BCG vaccine, Selman Waksman streptomycin and other anti-tuberculous drugs were developed. The famous scientist Robert Koch was able to isolate the tubercle bacillus and presented this extraordinary result to the society of Physiology in Berlin on 24 March 1882. In 1720, for the first time, the infectious origin of TB was conjectured by the English physician Benjamin Marten, while the first successful remedy against TB was the introduction of the sanatorium cure. The illness was known in England and France as "king's evil", and it was widely believed that persons affected could heal after a royal touch. In the Middle Ages, scrofula, a disease affecting cervical lymph nodes, was described as a new clinical form of TB. Tuberculosis (TB) is a contagious, infectious disease, due to Mycobacterium tuberculosis (MT) that has always been a permanent challenge over the course of human history, because of its severe social implications. ![]()
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